文献标引:雷建平.重新审视结核病免疫治疗研究的方向和方法[J/CD].中华临床医师杂志：电子版,2010,4(7):908-915.

参考文献:
[1]　Desvignes L，Ernst JD.Interferon-gamma-responsive nonhematopoietic cells regulate the immune response to Mycobacterium tuberculosis.Immunity,2009,31(6)：974-985.[PubMed]
[2]　Matsunaga I，Moody DB.Mincle is a long sought receptor for mycobacterial cord factor.J Exp Med,2009,206(13)：2865-2868.[PubMed]
[3]　Johnson BJ， Ress SR， Willcon P， et al.Clinical and immune respones of tuberculasis patients treated with low-dose IL-2 and multidrug therapy. Cytokines Mol Ther， 1995,1(3)：185-196.[PubMed]
[4]　王倩，张洁，黄淑萍，等.母牛分枝杆菌菌苗辅助治疗复治性及耐多药结核的Meta 分析.中国药房，2008,19(11)：838-841.
[5]　胡杰贵，胡先纬.抗结核药联用乌体林斯治疗肺结核疗效观察.疾病控制杂志，2003,7(1)：37-39.
[6]　宋敏娟，王冠莲，马秀丽，等.卡介菌多糖核酸注射液在复治菌阳性肺结核治疗中的疗效观察.临床肺科杂志，2008,13(4)：442-443.
[7]　徐苗，陈保文，沈小兵，等.耻垢分枝杆菌作为免疫调节剂的研究.中华微生物学和免疫学杂志，2005,25(9)：752-755.
[8]　和风云，何静，王玉龙.化疗并用黄芪注射液治疗复治肺结核33例.中国基层医药，2004,11(2)：232-233.
[9]　张才军，李莉，吴虢东，等.结核清注射剂对小鼠免疫调节的实验研究.昆明医学院学报，2008,29(1)：36-39.
[10]　郭昆鹏.左旋咪唑辅助治疗肺结核病临床分析.中国现代药物应用，2008,2(9)：37-38.
[11]　Sadagopal S，Braunstein M，Hager CC，et al.Reducing the activity and secretion of microbial antioxidants enhances the immunogenicity of BCG.PLoS One,2009,4(5)：e5531.[PubMed]
[12]　雷建平，熊国亮，胡群芳，等.化疗加用卡介苗免疫治疗预防耐多药结核病的研究.中华预防医学杂志，2008,42(2)：86-89.
[13]　雷建平.CD4＋CD8＋双阳(DP)T细胞与结核病及卡介苗治疗相关性研究.中国科技成果，2009,10(6)：58.
[14]　雷建平，彭燕，熊国亮，等.卡介苗免疫对大鼠抗结核发病和T淋巴细胞亚群的影响.中国预防医学杂志，2007,8(2)：81-84.
[15]　雷建平，彭燕，熊国亮，等.不同时期卡介苗免疫治疗对结核病大鼠疗效和CD4＋ CD8＋双阳(DP)T细胞的影响.中国防痨杂志，2006,28(6)：404-407.
[16]　da Fonseca DM，Silva CL，Wowk PF，et al.Mycobacterium tuberculosis culture filtrate proteins plus CpG Oligodeoxynucleotides confer protection to Mycobacterium bovis BCG-primed mice by inhibiting interleukin-4 secretion.Infect Immun,2009,77(12)：5311-5321.[PubMed]
[17]　Erokhin VV， Vasil′eva IA，Konopliannikov AG，et al.Systemic transplantation of autologous mesenchymal stem cells of the bone marrow in the treatment of patients with multidrug-resistant pulmonary tuberculosis.Probl Tuberk Bolezn Legk,2008(10)：3-6.[PubMed]
[18]　何球藻，吴厚生，曹雪涛.细胞与分子免疫学.上海：上海科学技术文献出版社，1997：12 -19,121-189.
[19]　陆德源.现代免疫学.2版.上海：上海科学技术出版社，1998：1-38,75-128,231-235.
[20]　Demangel C，Palendira U，Feng CG，et al.Stimulation of dendritic cells via CD40 enhances immune responses to Mycobacterium tuberculosis infection.Infect Immun,2001,69(4)：2456-2461.[PubMed]
[21]　Raja A.Immunology of tuberculosis.Indian J Med Res,2004,120(4)：213-232.[PubMed]
[22]　潘家华，楼皖玲，周浩泉，等.卡介苗配用腺苷接种提高巨噬细胞抗结核杆菌效能的研究.中华儿科杂志，2004,42(12)：932-935.
[23]　Venketaraman V，Dayaram YK，Talaue MT，et al.Glutathione and nitrosoglutathione in macrophage defense against Mycobacterium tuberculosis.Infect Immun,2005,73(3)：1886-1889.[PubMed]
[24]　Kusner DJ.Mechanisims of mycobacterial persistence in tuberculosis.Clin Immunol,2005,114(3)：239-247.[PubMed]
[25]　Vergne I，Chua J，Lee HH，et al.Mechanism of phagolysome biogenesis block viable Mycobacterium tuberculosis.Proc Natl Acad Sci U S A,2005,102(11)：4033-4038.[PubMed]
[26]　Verreck FA，de Boer T，Langenberg DM，et al.Human IL-23-producing type 1 macrophages promote but IL-10-producing type 2 macrophages subvert immunity to (myco)bacteria.Proc Natl Acad Sci U S A,2004,101(13)：4560-4565.[PubMed]
[27]　Saunders BM， Frank AA， Orme IM， et al. Interleukin-6 induces early gamma interferon production in the infected lung but is not required generation of specific immunity to Mycobacterium tuberculosis infection.Infect Immun,2000,68(6)：3322-3326.[PubMed]
[28]　Leal IS，Smedegrd B，Andersen P，et al.Interleukin-6 and interleukin-12 participate in induction of a type 1 protective T-cell response during vaccination with a tuberculosis subunit vaccine.Infect Immun,1999,67(11)：5747-5754.[PubMed]
[29]　Ladel CH，Blum C，Dreher A，et al.Lethal tuberculosis in interleukin-6-deficient mutant mice.Infect Immun,1997,65(11)：4843-4849.[PubMed]
[30]　Gansert JL，Kiessler V，Engele M，et al.Human NKT cells express granulysin and exhibit antimycobacterial activity.J Immunol,2003,170(6)：3154-3161.[PubMed]
[31]　Sugawara I，Yamada H，Mizuno S，et al.Mycobacterial infection in natural killer T cell knockout mice.Tuberculosis(Edinb),2002,82(2/3)：97-104.[PubMed]
[32]　Junqueira-Kipnis AP，Kipnis A，Jamieson A，et al.NK cells respond to pulnomary infection with Mycobacterium tuberculosis，but play a minimal role in protection.J Immunol,2003,171(11)：6039-6045.[PubMed]
[33]　Eruslanov EB，Lyadova IV，Kondratieva TK，et al.Neutrophil responses to Mycobacterium tuberculosis infection in genetically susceptible and resistant mice.Infect Immun,2005,73(3)：1744-1753.[PubMed]
[34]　Olmos S，Stukes S，Ernst JD.Ectopic activation of Mycobacterium tuberculosis-specific CD4＋ T cells in lungs of CCR7-/- mice.J Immunol,2010,184(2)：895-901.[PubMed]
[35]　雷建平.耐多药结核病治疗研究现状及警示[J/CD].中华临床医师杂志：电子版，2009,3(8)：1334-1341.
[36]　Tanghe A， Lefèvre P， Denis O， et al. Immunogenicity and protective efficacy of tuberculosis DNA vaccines encoding putative phosphate transport receptors. J Immunol， 1999,162(2)：1113-1119.[PubMed]
[37]　雷建平，李剑，邓国防，等.结核病小鼠T淋巴细胞亚群及其表达的四项细胞因子分析.中华结核和呼吸杂志，2008,31(11)：836-840.
[38]　Stenger S，Hanson DA，Teitelbaum R，et al.An antimicrobial activity of cytolytic T cells mediated by granulysin.Science,1998,282(5386)：121-125.[PubMed]
[39]　Jeevan A，Asherson GL.Recombinant interleukin-2 limits the replication of Mycobacterium lepraemurium and Mycobacterium bovis BCG in mice.Infect Immun,1988,56(3)：660-664.[PubMed]
[40]　汤红明，刘君炎，高立芬.IFN-γ与TNF联合治疗结核菌感染小鼠疗效及机理的研究.免疫学杂志，2001,17(6)：457-459.
[41]　要玉霞，刘传玉.干扰素辅助治疗耐多药结核病的疗效观察.中国防痨杂志，2003,25(1)：43-44.
[42]　Bruns H，Meinken C，Schauenberg P，et al.Anti-TNF immunotherapy reduces CD8＋ T cell-mediated antimicrobial activity against Mycobacterium tuberculosis in humans.J Clin Invest,2009,119(5)：1167-1177.[PubMed]
[43]　杨晓敏，董德琼，杨渝浩，等.白细胞介素7 对肺结核患者Th1/Th2平衡的调节作用.贵州医药，2005,29(2)：112-115.
[44]　Li Q.New mechanism of organophosphorus pesticide-induced immunotoxicity.J Nippon Med Sch,2007,74(1)：70-73.[PubMed]
[45]　赵和平，李清甫，张建设，等.抗结核药物联合胎盘转移因子治疗老年肺结核的研究.中华结核和呼吸杂志，1996,19(3)：187-188.
[46]　徐丽，李修范，朱惠华，等.抗结核药物联合口服转移因子治疗肺结核临床观察.白求恩医科大学学报，2001,27(6)：580.
[47]　于强，席启辉，高世定，等.胸腺肽辅助化疗浸润型肺结核68例疗效观察.安徽医药，2005,9(3)：180-181.
[48]　王晓华.胸腺因子D 治疗难治性肺结核疗效观察.临床肺科杂志，2001,6(4)：20-21.
[49]　邵玉霞，张暋，齐景宪，等.保尔佳治疗肺癌的疗效观察.河南医药信息，1995,11：34-35.
[50]　刘剑波，夏熙郑，齐景宪，等.保尔佳辅助肺结核化疗的临床及实验研究.河南医药信息，1995,16(11)：30-31.
[51]　佟玉平，李艳丽，张春梅.肺结核病人应用肺活素治疗前后的细胞因子及体液免疫水平检测.黑龙江医学，2008,32(5)：377.
[52]　Lowrie DB， Tascon RE， Bonato VL， et al. Therapy of tuberculosis in mice by DNA vaccination.Nature， 1999， 400(6741)：269-271.[PubMed]
[53]　Zhu D，Jiang S，Luo X.Therapeutic effects of Ag85B and MPT64 DNA vaccines in a murine model of Mycobacterium tuberculosis infection.Vaccine,2005,23(37)：4619-4624.[PubMed]
[54]　Silva CL， Bonato VL， Coelho-Castelo AA，et al.Immunotherapy with plasmid DNA encoding mycobacterial hsp65 in association with chemotherapy is a more rapid and efficient form of treatment for tuberculosis in mice.Gene Ther,2005,12(3)：281-287.[PubMed]
[55]　Liang Y，Wu X，Zhang J，et al. The treatment of mice infected with multi-drug-resistant Mycobacterium tuberculosis using DNA vaccines or in combination with rifampin.Vaccine,2008,26(35)：4536-4540.[PubMed]
[56]　Lindblad EB，Elhay MJ，Silva R，et al.Adjuvant modulation of immune responses to tuberculosis subunit vaccines.Infect Immun,1997,65(2)：623-629.[PubMed]
[57]　Brandt L，Elhay M，Rosenkrands I，et al.ESAT-6 subunit vaccination against Mycobacterium tuberculosis.Infect Immun,2000,68(2)：791-795.[PubMed]
[58]　Doherty TM，Andersen P.Vaccines for tuberculosis：novel concepts and recent progress.Clin Microbiol Rev,2005,18(4)：687-702.[PubMed]
[59]　Krieg AM， Yi AK， Hartmann G. Mechanisms and therapeutic applications of immune stimulatory cpG DNA.Pharmacol Ther,1999,84(2)：113-120.[PubMed]
[60]　Delogu G，Fadda G.The quest for a new vaccine against tuberculosis.J Infect Dev Ctries,2009,3(1)：5-15.[PubMed]